Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B5, also known as Pantothenic Acid, plays a scientifically established role in mitochondrial function. It is an essential precursor for the synthesis of coenzyme A (CoA), which is a critical cofactor in the mitochondrial energy production pathways, including the citric acid (Krebs) cycle and fatty acid oxidation. These metabolic pathways are central to ATP production—the main energy currency of cells—and occur within the mitochondria. Deficiency in pantothenic acid impairs CoA synthesis, leading to compromised energy metabolism and mitochondrial function, as demonstrated in multiple animal and in vitro studies. In humans, overt deficiency is rare but results in symptoms such as fatigue and neurological disturbances, likely due to impaired energy production. While direct clinical trials supplementing pantothenic acid for mitochondrial disorders in humans are limited, the biochemical necessity of B5 for CoA synthesis and mitochondrial energy metabolism is well-accepted and forms the basis for its inclusion in mitochondrial support formulations. Most evidence is mechanistic and based on the essential nature of B5 in mitochondrial pathways rather than large-scale clinical intervention trials. Nevertheless, the scientific consensus strongly supports the need for adequate pantothenic acid for normal mitochondrial structure and function.

More about Vitamin B5 (Pantothenic Acid)
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Vitamin B5 (Pantothenic Acid)

Acetylcholine
Adrenal Cortex
Adrenal Glands
Brain
Cortisol
Digestive System
Glandular System
Hair
Immune System
Mitochondria
Nerves
Skin

Products containing Vitamin B5 (Pantothenic Acid)

We currently have no products on Vitabase that contain this ingredient.