Evidence supporting the use of: Vitamin C (Ascorbate)
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbate) has a scientifically established role as an essential micronutrient and antioxidant. Its primary functions involve collagen synthesis, immune function, and acting as a cofactor in several enzymatic reactions. Regarding mitochondrial support, Vitamin C indirectly supports mitochondrial health through its antioxidant properties, helping to neutralize reactive oxygen species (ROS) generated by mitochondrial respiration. Excessive ROS can damage mitochondrial DNA, proteins, and lipids, impairing mitochondrial function.

There is some evidence from cell culture and animal studies indicating that ascorbate may preserve mitochondrial integrity under oxidative stress and may play a role in maintaining mitochondrial membrane potential. Some in vitro studies suggest Vitamin C can protect against mitochondrial dysfunction induced by toxins or metabolic stress. However, direct evidence from human studies showing that vitamin C supplementation significantly improves mitochondrial function in healthy individuals or in mitochondrial disease is limited and generally not robust.

Thus, while there is a scientific rationale for Vitamin C’s supportive role in protecting mitochondria from oxidative damage, the evidence for direct, clinically meaningful mitochondrial support in humans is modest. Most clinical recommendations for vitamin C focus on preventing deficiency and supporting general antioxidant status rather than specifically targeting mitochondrial health.

More about Vitamin C (Ascorbate)
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caffeine
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creatine monohydrate
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fructose
fruit and vegetable blend (proprietary)
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gooseberry
grape
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hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
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mackerel
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malic acid
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manganese
maqui berry
marine lipid
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medium chain triglycerides (MCT)
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niacin (vitamin B3)
niacinamide (vitamin B3)
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pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
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ubiquinol
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vegetable and fruit blend (proprietary)
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Products containing Vitamin C (Ascorbate)

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