Evidence supporting the use of: Vitamin E (tocotrienol unspecified)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin E, particularly in its tocotrienol form, has been investigated for its potential role in supporting mitochondrial health. Mitochondria are highly susceptible to oxidative damage due to their role in cellular energy production and generation of reactive oxygen species (ROS). Tocotrienols, a lesser-known subclass of the Vitamin E family, have demonstrated potent antioxidant capabilities, often exceeding those of tocopherols (the more common form of Vitamin E). Several in vitro and animal studies suggest that tocotrienols can protect mitochondrial membranes from oxidative stress, preserve mitochondrial function, and reduce mitochondrial dysfunction associated with aging and disease states (source). For example, tocotrienols have been shown to improve mitochondrial respiration and decrease markers of oxidative damage in models of neurodegenerative diseases and metabolic syndrome. However, human clinical data are limited, and most evidence comes from preclinical studies. The plausible mechanisms include direct scavenging of free radicals, modulation of mitochondrial biogenesis, and improvement of mitochondrial membrane integrity. Thus, while there is scientific rationale and some supportive evidence for the use of tocotrienols in mitochondrial support, definitive conclusions await more robust human trials.
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adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
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greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
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quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
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vegetable and fruit blend (proprietary)
vitamin B
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vitamin D3
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Other body systems supported by Vitamin E (tocotrienol unspecified)
ArteriesBlood
Brain
Capillaries
Circulatory System
Heart
Immune System
Male Reproductive System
Mitochondria
Nerves
Reproductive System
Skin
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