Evidence supporting the use of: Vitamine E (mixed tocotrienols)
For the body system: Mitochondria
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Vitamin E, particularly in the form of mixed tocotrienols, has garnered scientific interest for its role in mitochondrial health. The mitochondria are particularly susceptible to oxidative stress due to their role in cellular respiration and energy production, which generates reactive oxygen species (ROS) as byproducts. Vitamin E is a lipid-soluble antioxidant, and both tocopherols and tocotrienols can protect mitochondrial membranes from lipid peroxidation. Some cell and animal studies have demonstrated that tocotrienols, in particular, may be more effective than tocopherols at preventing oxidative damage within the mitochondria. There is evidence that tocotrienols can preserve mitochondrial function, reduce oxidative injury, and modulate mitochondrial biogenesis pathways in preclinical models.
However, clinical studies in humans are limited, and the majority of evidence comes from in vitro or animal studies. While Vitamin E deficiency is known to impair mitochondrial function, supplementation in otherwise healthy humans has not been conclusively shown to enhance mitochondrial health or function. The evidence suggests a potential benefit, especially under conditions of increased oxidative stress, but this remains to be validated in large-scale, high-quality human trials.
In summary, there is a scientific basis for the use of mixed tocotrienols to support mitochondrial health, but the current level of evidence—particularly in humans—is modest, justifying a rating of 2 out of 5.
More about Vitamine E (mixed tocotrienols)
More about Mitochondria
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bovine liver
caffeine
catechins
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creatine monohydrate
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flavonols
fructose
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glycerophosphocholine (GPC)
gooseberry
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hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
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medium chain triglycerides (MCT)
melatonin
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niacin (vitamin B3)
niacinamide (vitamin B3)
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pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
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quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
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vegetable and fruit blend (proprietary)
vitamin B
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Alpha polylactate
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adenosine triphosphate (ATP)
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Caffeic Acid
Centrophenoxine
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Cocarboxylase
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Coenzyme A
Cardiolipin
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Other body systems supported by Vitamine E (mixed tocotrienols)
ArteriesBlood
Brain
Capillaries
Circulatory System
Female Reproductive System
Heart
Immune System
Liver
Male Reproductive System
Mitochondria
Nerves
Prostate
Skin
Testes