Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Zinc lipoic acid is a supplement that combines zinc, an essential trace mineral, with alpha-lipoic acid (ALA), a naturally occurring antioxidant. Both ingredients have mechanistic and some clinical evidence supporting their role in supporting mitochondrial function:

• Zinc: Zinc is a cofactor for several enzymes involved in mitochondrial energy production, such as superoxide dismutase (SOD), which helps manage oxidative stress within mitochondria. Zinc deficiency has been linked to impaired mitochondrial function and increased oxidative damage in preclinical models.
• Alpha-lipoic acid (ALA): ALA directly participates as a coenzyme in mitochondrial energy metabolism (specifically in the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes). It also functions as a potent antioxidant, regenerating other antioxidants and reducing oxidative stress, which is essential for maintaining mitochondrial integrity. Human studies have shown that ALA supplementation can improve mitochondrial function in certain contexts, such as diabetic neuropathy and age-related decline.

However, while both zinc and ALA have roles in mitochondrial health, direct clinical evidence for the combined supplement "zinc lipoic acid" in supporting mitochondrial function in humans is limited. Most evidence comes from studies examining the individual components rather than the combined form. Thus, the scientific justification is moderate (rated 3), primarily based on mechanistic plausibility and some supportive clinical data for the individual ingredients.

More about Zinc lipoic acid
More about Mitochondria

Other ingredients that support Mitochondria

7-Keto-DHEA
acetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
bovine liver
caffeine
catechins
citicoline
coenzyme Q10 (CoQ10)
coffee fruit
copper
creatine monohydrate
d-alpha tocopherol
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
fructose
fruit and vegetable blend (proprietary)
glycerophosphocholine (GPC)
gooseberry
grape
greens blend (proprietary)
hesperetin
knotweed
krill oil
l-carnitine
l-carnosine
l-citrulline
l-glutathione
l-glycine
l-taurine
lentinula edodes mycelia
linoleic acid (LA)
liquid liver fractions
luteolin
mackerel
magnesium
maitake mushroom
malic acid
maltodextrin
maltose
manganese
maqui berry
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
moringa
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oleanolic acid
pantethine
pantothenic acid (vitamin B5)
phenolic acids
phosphatidylcholine
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
quinoa
resveratrol
rhodiola
riboflavin (vitamin B2)
rosemary
sardines
selenium
black ginger
spinach
starch
stearic acid
strawberry
succinic acid
sulforaphane glucosinolate
thiamin (vitamin B1)
tocotrienols
trans-geranylgeraniol
trans-pterostilbene
tributyrin
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin B
vitamin B
vitamin D3
water
watermelon
β-nicotinamide mononucleotide (NMN)
lingzhi
cistanche
ganoderma
electrolytes blend (proprietary)
polyphenols
trace minerals
fulvic acid
goji berry
herbal blend (proprietary)
algae
AMP-activated protein kinase (AMPK)
thyroid substance
ashitaba
1,3,7-Trimethylpurine-2,6-dione
5-Aminoimidazole-4-Carboxamide Ribonucleotide
Alpha polylactate
Apigenin
Alpha-Lipoic Acid
Ampelopsin
adenosine triphosphate (ATP)
Animal protein
Beta-hydroxybutyrate
Beef liver
berry
Caffeic Acid
Centrophenoxine
Camellia sinensis
Cardarine
Cocarboxylase
Capsinoids
Coenzyme A
Cardiolipin
Cyanidin
Capsiate
Chocolate
Creatine
C-Phycocyanin
Dihydrolipoic Acid
D-Ribose
Eriocitrin
Ergothioneine
glucose
Ketone Salts

Other body systems supported by Zinc lipoic acid

Brain
Hair
Immune System
Mitochondria
Nerves

Products containing Zinc lipoic acid

We currently have no products on Vitabase that contain this ingredient.