Evidence supporting the use of: Bifidobacterium longum
For the health condition: Mood Swings

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium longum has recently attracted scientific interest for its potential role in mood regulation, owing to the emerging understanding of the gut-brain axis. Preclinical studies (primarily in animal models) have shown that supplementation with B. longum can modulate neurotransmitter levels, reduce inflammatory markers, and ameliorate behaviors associated with anxiety and depression. A few small-scale human clinical trials have explored the effects of B. longum on psychological well-being. For example, a randomized, double-blind, placebo-controlled trial published in 2016 found that B. longum 1714 supplementation reduced stress and improved memory in healthy volunteers. Another study demonstrated that a combination of B. longum and Lactobacillus helveticus reduced symptoms of depression and anxiety in adults with mild-to-moderate symptoms.

However, while these results are promising, the direct evidence supporting the use of B. longum specifically for mood swings is limited. Most available studies focus on general mood, anxiety, or depressive symptoms rather than mood instability or bipolar spectrum conditions. The mechanisms are thought to involve modulation of the hypothalamic-pituitary-adrenal (HPA) axis, immune signaling, and microbial metabolites affecting the central nervous system.

In summary, while there is a growing body of scientific literature suggesting that B. longum may positively influence mood and psychological health, direct evidence for its use in treating or supporting mood swings is still preliminary. The current evidence base merits a rating of 2 out of 5, indicating weak but emerging scientific support.

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