Evidence supporting the use of: Phenylalanine
For the health condition: Mood Swings

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phenylalanine is an essential amino acid that serves as a precursor to tyrosine, which in turn is a precursor to catecholamine neurotransmitters such as dopamine, norepinephrine, and epinephrine. The interest in phenylalanine for mood support stems from its role in neurotransmitter synthesis, which is crucial for regulating mood. Some small clinical studies and case reports have investigated the use of DL-phenylalanine (a mixture of D- and L- forms) or L-phenylalanine for conditions like depression, which can present with mood swings. For example, limited evidence from the 1970s and 1980s suggested mild mood-improving effects in some depressive patients, theorizing that increased phenylalanine intake could boost neurotransmitter production. However, larger and more recent placebo-controlled trials are lacking, and results have been inconsistent or inconclusive. The scientific consensus is that while the biological rationale exists, robust clinical evidence supporting phenylalanine for mood swings specifically is weak. Furthermore, phenylalanine supplementation is contraindicated in individuals with phenylketonuria (PKU) and may interact with certain medications. In summary, while there is a plausible scientific mechanism and some preliminary data, the evidence for phenylalanine’s efficacy in treating mood swings is limited and not well-established by current standards.

More about Phenylalanine
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Other health conditions supported by Phenylalanine

Depression
Mood Swings

Products containing Phenylalanine

We currently have no products on Vitabase that contain this ingredient.