Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Doxylamine succinate is scientifically validated for use in treating morning sickness (nausea and vomiting of pregnancy) when combined with pyridoxine (vitamin B6). This combination, originally marketed as Bendectin in the United States, is the only medication specifically FDA-approved for this indication. Multiple randomized controlled trials and meta-analyses have demonstrated its efficacy and safety. The American College of Obstetricians and Gynecologists (ACOG) and other international guidelines recommend doxylamine-pyridoxine as a first-line pharmacologic therapy for morning sickness that does not respond to dietary and lifestyle changes.

Doxylamine is an antihistamine with antiemetic (anti-nausea) properties. When used alone or with pyridoxine, it reduces the frequency and severity of nausea and vomiting in pregnant women. Decades of research, including large cohort and case-control studies, have shown no significant increase in risk of birth defects or adverse pregnancy outcomes with its use.

Historically, concern about teratogenicity led to the withdrawal of Bendectin from the U.S. market in 1983, but subsequent epidemiological studies refuted these concerns. The drug combination is still widely used in Canada (as Diclectin) and other countries. Its strong safety profile and proven efficacy make doxylamine-pyridoxine the standard of care for pharmacological management of morning sickness.

More about Doxylamine succinate
More about Morning Sickness

Other ingredients used for Morning Sickness

chamomile
ginger
licorice root
peppermint oil
vitamin B6
Doxylamine succinate

Other health conditions supported by Doxylamine succinate

Insomnia
Morning Sickness
Nausea and Vomiting
Sleep (restless and disturbed)

Products containing Doxylamine succinate

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