Evidence supporting the use of: Vitamin B6 (pyridoxine)
For the health condition: Morning Sickness

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6 (pyridoxine) is scientifically validated as a treatment for morning sickness (nausea and vomiting of pregnancy). Multiple randomized controlled trials and systematic reviews have assessed its efficacy, with many showing a significant reduction in nausea symptoms compared to placebo. The American College of Obstetricians and Gynecologists (ACOG) and other expert bodies recommend vitamin B6 (often at doses of 10-25 mg three times daily) as a first-line therapy for mild to moderate nausea and vomiting in pregnancy, either alone or in combination with doxylamine.

The mechanism by which vitamin B6 alleviates nausea is not fully understood, but it may involve its role in neurotransmitter synthesis, including serotonin and dopamine, which can affect nausea pathways. Importantly, studies have not shown an increased risk of fetal malformations or adverse pregnancy outcomes with recommended doses of vitamin B6, making it a safe option during pregnancy.

In summary, vitamin B6 is widely used for the management of morning sickness based on a solid foundation of clinical research. While not universally effective for every patient, its favorable safety profile and demonstrated efficacy in reducing nausea make it a scientifically supported treatment for this common pregnancy symptom.

More about Vitamin B6 (pyridoxine)
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