Evidence supporting the use of: Vitamin B6 (Pyridoxine HCl)
For the health condition: Morning Sickness

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6 (Pyridoxine HCl) is scientifically validated as a treatment for morning sickness (nausea and vomiting during pregnancy). Multiple clinical trials and systematic reviews have assessed its efficacy. Guidelines from reputable bodies such as the American College of Obstetricians and Gynecologists (ACOG) recommend vitamin B6 as a first-line therapy for mild to moderate nausea and vomiting in pregnancy. The mechanism is not fully understood, but B6 is thought to play a role in neurotransmitter synthesis that may impact the vomiting center in the brain.

A 2014 Cochrane review found that vitamin B6 is more effective than placebo in reducing the severity of nausea (though not always vomiting), and the evidence supports a benefit over placebo for women with mild-to-moderate symptoms. Doses typically studied range from 10-25 mg three times daily, and these doses are considered safe for use in pregnancy. Vitamin B6 is also commonly used in combination with doxylamine, another agent with demonstrated efficacy.

In summary, there is strong scientific evidence (rating: 4/5) for the use of vitamin B6 in treating morning sickness. Its use is recommended by clinical guidelines, supported by randomized controlled trials, and considered safe at recommended doses during pregnancy.

More about Vitamin B6 (Pyridoxine HCl)
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