Evidence supporting the use of: Vitamin B6 (pyridoxine hydrochloride)
For the health condition: Morning Sickness

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6 (pyridoxine hydrochloride) is supported by scientific evidence for the treatment of morning sickness (nausea and vomiting in pregnancy). Several randomized controlled trials and meta-analyses have investigated its efficacy. A 2014 Cochrane review found that Vitamin B6 is more effective than placebo at reducing the severity of nausea, though not always vomiting. Dosages in studies typically range from 10 to 25 mg, taken three times daily. The mechanism is not fully understood, but Vitamin B6 is thought to play a role in neurotransmitter synthesis, which may impact pathways involved in nausea.

Major guidelines, including those from the American College of Obstetricians and Gynecologists (ACOG), recommend Vitamin B6 as a first-line therapy for mild to moderate nausea and vomiting in pregnancy. It is often used alone or in combination with doxylamine. Importantly, studies have shown no evidence of harm to the fetus at recommended doses, making it a relatively safe intervention.

While not universally effective for all pregnant individuals, the evidence base for Vitamin B6 is robust compared to many other interventions for morning sickness. Its recommendation by authoritative bodies further supports its use for this indication.

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