Aloe polysaccharides, particularly acemannan, are bioactive compounds found in Aloe vera gel that have been investigated for their effects on mucosal tissues. Scientific studies have demonstrated that aloe polysaccharides can support the integrity and repair of mucus membranes, especially in the gastrointestinal tract. In vitro and animal studies indicate that these polysaccharides may enhance epithelial cell proliferation and migration, promote wound healing, and exhibit anti-inflammatory and immunomodulatory effects. For example, a 2012 review published in the journal Phytotherapy Research noted that Aloe vera gel can accelerate the healing of oral mucositis and gastric ulcers, likely due to its polysaccharide content.

Human clinical trials are more limited but suggest potential benefits. A double-blind, placebo-controlled trial published in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology (2007) found that topical application of Aloe vera gel reduced the severity of oral lichen planus, a condition affecting the oral mucus membranes. Another study in Journal of Ethnopharmacology (2005) reported improved healing rates in patients with peptic ulcers using Aloe vera preparations.

While evidence is promising, most studies involve whole Aloe vera gel rather than isolated polysaccharides, and there is variability in product composition and study quality. Overall, there is moderate scientific support (rating: 3/5) for the use of aloe polysaccharides in supporting mucus membrane health, especially for oral and gastrointestinal applications.