Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Boneset (Eupatorium perfoliatum) has a long history of traditional use in supporting the mucus membranes, particularly in the context of respiratory illnesses such as colds, influenza, and bronchitis. Native American tribes and later European settlers in North America commonly used boneset as an herbal remedy for "breakbone fever" (dengue) and to alleviate symptoms of colds and flu, such as cough and congestion. The herb was typically prepared as a tea or tincture to promote sweating and help "break" fevers, with the belief that it could soothe inflamed or irritated mucus membranes in the respiratory tract.

While some laboratory studies suggest that boneset contains compounds with anti-inflammatory and immune-modulating properties, there is insufficient scientific evidence from clinical trials to confirm its efficacy for supporting the mucus membranes specifically. Most of its use is rooted in traditional herbal medicine rather than rigorous scientific validation. As such, the evidence for its effectiveness in this context is considered weak (rated 2/5), primarily based on historical and ethnobotanical sources.

It is important to note that boneset can be toxic in large amounts due to the presence of pyrrolizidine alkaloids, so its use should be approached with caution.

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