Evidence supporting the use of: Flavonones (unspecified)
For the body system: Mucus Membranes
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Flavonones, a subclass of flavonoids commonly found in citrus fruits and other plants, have demonstrated scientifically validated effects that are relevant to the support of mucus membranes. These compounds, which include hesperidin, naringin, and eriodictyol, are known for their antioxidant, anti-inflammatory, and cytoprotective properties. Research indicates that flavonones can help maintain the integrity of epithelial tissues, which line many mucus membranes in the respiratory, digestive, and genitourinary tracts. For example, several in vitro and animal studies have shown that flavonones can reduce oxidative stress and inflammation in mucosal tissues, aiding in their protection and repair.
Specific studies have demonstrated that naringin and hesperidin can modulate inflammatory pathways (such as the NF-κB pathway), reduce the production of pro-inflammatory cytokines, and increase the expression of protective mucins, all of which are relevant to the health of mucus membranes. While direct clinical evidence in humans is limited, the mechanistic and preclinical data provide a reasonable scientific basis for the use of flavonones in supporting mucus membrane health. However, more well-controlled human studies are needed to confirm these benefits and to establish optimal dosing and safety.
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