Evidence supporting the use of: Gamma Linolenic Acid
For the body system: Mucus Membranes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Gamma Linolenic Acid (GLA) is an omega-6 fatty acid found primarily in plant oils such as evening primrose oil, borage oil, and black currant seed oil. There is moderate scientific evidence suggesting that GLA may help support the health of mucus membranes, particularly in the context of conditions characterized by dryness or inflammation, such as Sjögren's syndrome or atopic dermatitis. GLA is a precursor to dihomo-gamma-linolenic acid (DGLA), which can be further metabolized into anti-inflammatory eicosanoids. Some clinical trials have shown that GLA supplementation can improve symptoms of dry eye and dry mouth in individuals with Sjögren’s syndrome, a disease marked by destruction of mucus-secreting glands. Other studies have noted improvement in skin barrier function and reduced inflammation in atopic dermatitis, indirectly supporting mucus membrane integrity.

However, the evidence is not uniformly strong. While some randomized controlled trials and systematic reviews support benefit, others report marginal or no significant improvement over placebo. The mechanism by which GLA may benefit mucus membranes is thought to stem from its role in modulating inflammatory responses and improving lipid composition in epithelial tissues, which may reduce dryness and irritation. Overall, GLA is scientifically investigated for supporting mucus membranes, but further well-powered studies are needed to establish conclusive efficacy.

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Products containing Gamma Linolenic Acid

We currently have no products on Vitabase that contain this ingredient.