Evidence supporting the use of: Glycyrrhizic acid
For the body system: Mucus Membranes
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Glycyrrhizic acid, a primary active compound found in licorice root (Glycyrrhiza glabra), has been traditionally used to soothe and support mucus membranes, particularly in the respiratory and gastrointestinal tracts. Scientifically, glycyrrhizic acid exhibits several pharmacological properties relevant to the protection and healing of mucus membranes. Studies have demonstrated its anti-inflammatory and mucoprotective effects, which help reduce irritation and promote healing in tissues such as the gastric lining and respiratory tract epithelium. For example, glycyrrhizic acid has been shown to increase mucus production in the stomach, offering a protective barrier against gastric ulcers induced by various irritants. Additionally, its antiviral activities may benefit the upper respiratory tract by reducing viral-induced inflammation of mucus membranes. However, while preclinical (animal and in vitro) studies are generally supportive, robust clinical trials in humans are limited, and most data come from traditional use or observational studies rather than large-scale randomized controlled trials. Therefore, while there is scientific rationale and some supportive evidence for using glycyrrhizic acid to support mucus membranes, the overall evidence base is moderate, justifying a rating of 3 out of 5.
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