Glycyrrhizin is a major bioactive compound found in licorice root (Glycyrrhiza glabra). Its use to support mucus membranes, particularly in the gastrointestinal and respiratory tracts, is supported by both traditional medicine and scientific research. Glycyrrhizin exhibits anti-inflammatory, demulcent (soothing), and mucoprotective properties. These actions are believed to help protect and heal mucus membranes by reducing inflammation and promoting mucous secretion.

Scientific studies have demonstrated glycyrrhizin’s ability to modulate inflammatory pathways, inhibit certain viruses, and encourage mucous production. For example, research has shown that glycyrrhizin can inhibit the activity of enzymes like cyclooxygenase and lipoxygenase, which are involved in the inflammatory response. Animal and in vitro studies suggest that glycyrrhizin can help protect the gastric mucosa from damage due to stress or irritants, and may enhance the production of protective mucus. Additionally, clinical use in conditions such as gastric ulcers and sore throat further supports its mucoprotective effects.

However, most clinical studies are small or preliminary, and adverse effects such as hypertension and hypokalemia limit its use. While traditional use is strong, the scientific evidence, though promising, is not yet robust or comprehensive, especially in large human trials. Therefore, glycyrrhizin’s use for supporting mucus membranes is best described as having moderate scientific support.