Polygonatum, commonly known as Solomon's Seal, has a long history of use in traditional medicine systems, particularly in Chinese herbal medicine. In Traditional Chinese Medicine (TCM), Polygonatum species (notably Polygonatum sibiricum and Polygonatum odoratum) are used as a yin tonic and are believed to moisten dryness in the lungs and nourish the mucus membranes. The herb is said to benefit the respiratory tract, soothe dry throat, and support fluid balance, which indirectly relates to the maintenance and support of healthy mucus membranes.

The traditional use is primarily based on empirical observation rather than rigorous scientific studies. While some modern phytochemical analyses have identified polysaccharides, saponins, and other constituents that may have immunomodulatory or soothing properties, direct scientific studies specifically confirming the efficacy of Polygonatum for mucus membrane support are lacking. No high-quality clinical trials exist that evaluate its impact on the mucus membranes of the respiratory, digestive, or reproductive systems. Thus, its use for this purpose remains rooted in traditional practice, with a moderate level of historical support but limited scientific validation.

In summary, while Polygonatum is traditionally used to support mucus membranes, particularly in TCM, the evidence is primarily historical, and scientific validation remains limited.