Sanicle (Sanicula europaea), also known as wood sanicle or self-heal, has a long history of traditional herbal use in Europe, particularly for its purported benefits to wound healing, inflammation, and mucous membrane health. In various traditional European herbal texts, sanicle was recommended as a remedy for mouth and throat irritations, ulcers, and inflammations of the mucous membranes. The leaves and roots were often used in decoctions or gargles to soothe sore throats, mouth ulcers, and other minor mucosal irritations. These uses were largely based on empirical experience and the plant’s astringent properties, which were thought to help tighten and protect mucous tissues. However, there is minimal modern scientific research specifically validating these uses. The available studies on sanicle’s phytochemistry indicate the presence of saponins, flavonoids, and tannins, which are compounds known for their potential anti-inflammatory and astringent effects. Despite this, there have been no robust clinical trials or significant pharmacological studies focusing on sanicle’s effects on the mucus membranes in humans. Thus, its use in supporting the mucous membranes is justified primarily by traditional herbal practices rather than contemporary scientific evidence. As such, it receives a modest evidence rating, reflecting traditional support with limited modern validation.