Evidence supporting the use of: Serrapeptase
For the body system: Mucus Membranes
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Serrapeptase is a proteolytic enzyme originally isolated from bacteria in the intestines of silkworms. It has been investigated for its ability to reduce inflammation, break down non-living tissue, and modulate mucus viscosity. Several small clinical studies and in vitro experiments have examined serrapeptase's potential to reduce viscosity and thickness of mucus secretions, particularly in conditions like chronic sinusitis and bronchitis. For example, a study published in the journal Ear, Nose & Throat Journal (2004) showed that serrapeptase could improve symptoms and reduce nasal secretion viscosity in patients with chronic sinusitis. Another earlier study (Nakamura et al., 2003) indicated potential benefit in reducing sputum viscosity among patients with chronic respiratory diseases.
Despite these findings, the quality of evidence is limited by small sample sizes, lack of large-scale randomized controlled trials, and variability in study design. There is a plausible mechanism whereby serrapeptase could support mucus membrane health by breaking down excess or thickened mucus, but robust, high-quality clinical evidence is lacking. Therefore, while there is scientific rationale and some preliminary support, it is not yet a well-established or universally accepted intervention for mucus membrane support. The evidence rating is moderate to low (2 out of 5), reflecting promising but inconclusive data.
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akkermansia muciniphilaaloe vera
barley
basil
bayberry
beta-carotene
bilberry
bisabolol
blackberry
broccoli
ceramides
chamomile
citrus bioflavonoids
clove
coating
colostrum
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dandelion
fruit and vegetable blend (proprietary)
glehnia root
glycerin
goldenseal
onion
horseradish
hypromellose
l-cysteine
l-threonine
lactobacillus crispatus
lactobacillus jensenii
lactobacillus salivarius
lactoferrin
lactoperoxidase
lemon
licorice root
marshmallow
methylmethionine sulfonium chloride (vitamin U)
mint
mixed carotenoids
mucin
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
nettle
niacin (vitamin B3)
okra
olive
omega-7 fatty acids
ophiopogon root
oregon grape
pear
perilla
plantain
platycodon root
prebiotic blend (proprietary)
raspberry
riboflavin (vitamin B2)
rose oil
sage
slippery elm bark
sorbitol
thyme
vitamin A
vitamin C
vitamin E
water
xylitol
zhejiang fritillary
zinc
yellow root
boneset
mullein
chickweed
cardamom
lobelia
capsicum
mugwort
malabar nut
hedychium spicatum
tylophora
yarrow
moss
fritillaria
myrrh
yerba santa
elecampane
coltsfoot
zanthoxylum
eucalyptus
menthol oil
aster root
stillingia
white oak
horehound
herbal blend (proprietary)
cayenne pepper
Agastache
acacia
Agrimony
Allicin
Alchornea
Asarum heterotropoides
Arrowroot
Acemannan
Adenophora
Asarabacca
Arisaema
Asarum sieboldii
Bee Propolis
Black Seed
Baikal Skullcap
Bryonia
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Bidens pilosa
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Bistort
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Barleria
Bougainvillea
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Boswellia
Bethroot
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Bioflavonoids
Butterbur
Bee products
Borage
Balloon Flower
Belamcanda
Bird's nest
Calendula
Colloidal Silver
Cod Liver Oil
Carvacrol
Citrus
Cineole
Cornflower
Cajuput
Cantaloupe
Catechu
Centipeda
Cistus
Cubeb
Cowslip
Cranesbill
Carotene (unspecified)
Chekiang Fritillary
Collinsonia
Chondrus
Devil's Club
European Elder
English Horsemint
English Elm
Echinacea
Elder
European Field Elm
Eucheuma
Elephant's Head
European-Five Finger Grass
Ellagitannin
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Goldthread
Glycosaminoglycans
Mallow
Mimosa
Rose
Other body systems supported by Serrapeptase
ArteriesBlood
Bronchials
Circulatory System
Lungs
Mucus Membranes
Sinuses