Evidence supporting the use of: Flavones (various)
For the health condition: Multiple Sclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Flavones are a class of polyphenolic compounds found abundantly in various fruits, vegetables, and medicinal plants. There is emerging scientific interest in their potential neuroprotective and anti-inflammatory properties relevant to Multiple Sclerosis (MS), a chronic autoimmune disorder characterized by inflammation and demyelination in the central nervous system. Preclinical studies—primarily in vitro and in animal models—have shown that certain flavones (such as luteolin, apigenin, and baicalein) can downregulate pro-inflammatory cytokines, inhibit activation of microglia, and reduce oxidative stress, all of which are implicated in MS pathology.

However, robust clinical evidence in humans is lacking. Only a few small-scale pilot studies and case reports have explored the effects of flavone-rich extracts or supplements in people with MS, and these studies are typically underpowered and preliminary. Most evidence supporting the use of flavones for MS comes from laboratory investigations, not from controlled human trials. Thus, while there is a plausible scientific rationale for their investigation, and early-stage data suggest potential benefit, the evidence remains weak and insufficient to recommend flavones as a primary or adjunct therapy for MS outside of a research setting.

In summary, the use of flavones for MS is supported by limited scientific evidence, and more rigorous clinical research is needed to establish efficacy and safety in this context.

More about Flavones (various)
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Products containing Flavones (various)

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