Evidence supporting the use of: Alpha-ketoisocaproic acid
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-ketoisocaproic acid (KIC) is a keto acid derived from the metabolism of the branched-chain amino acid leucine. Its use for supporting muscle tone or treating conditions of reduced muscle tone (hypotonia) is based on its role as an intermediate in amino acid metabolism and energy production in muscle tissue. Some scientific studies have investigated KIC, often in combination with other amino acids or as part of keto acid supplements, for their potential to reduce muscle breakdown and promote protein synthesis, particularly in settings of muscle wasting or exercise-induced stress.

However, the evidence for KIC’s efficacy in improving or restoring muscle tone specifically is limited. Most research focuses on its use in patients with chronic renal failure to reduce uremic toxin production and supplement essential amino acids without increasing nitrogen load. A few small clinical trials and animal studies suggest that KIC, especially when combined with other branched-chain keto acids or amino acids, may help preserve muscle mass or attenuate muscle degradation in catabolic states, but results are mixed and not directly related to muscle tone restoration.

Overall, while there is a plausible scientific rationale for using KIC in muscle metabolism and some limited evidence from muscle wasting models, there is insufficient high-quality clinical data to firmly support its routine use for improving muscle tone in healthy individuals or in those with hypotonia. The evidence is therefore rated as 2 out of 5.

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Other health conditions supported by Alpha-ketoisocaproic acid

Athletic and Exercise Aids
Body Building
Exercise
Muscle Tone (lack of)
Wasting

Products containing Alpha-ketoisocaproic acid

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