Evidence supporting the use of: Casein
For the health condition: Muscle Tone (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Casein is a milk-derived protein commonly used in nutritional supplements, especially in sports and fitness contexts. Its primary claim to supporting or treating "muscle tone" is based on its slow digestion and absorption profile, which provides a sustained release of amino acids into the bloodstream. Multiple randomized controlled trials and meta-analyses have demonstrated that casein supplementation, particularly when consumed before sleep, enhances muscle protein synthesis and helps reduce muscle protein breakdown overnight (Res PT et al., 2013). This can be especially beneficial for individuals experiencing reduced muscle tone due to inactivity, aging (sarcopenia), or illness.
Casein’s efficacy is considered comparable to other complete proteins like whey, though its slower absorption makes it particularly suited for prolonged periods without dietary protein intake. Scientific evidence supports its effectiveness in increasing lean muscle mass and strength when combined with resistance training. However, it should be noted that “muscle tone” is not a clinical term and generally refers to the appearance or firmness of muscles, which is more directly influenced by muscle mass and physical activity than by any single dietary factor. Overall, casein is a scientifically validated ingredient for supporting muscle maintenance and growth, thereby indirectly supporting what is commonly referred to as "muscle tone."
Other ingredients used for Muscle Tone (lack of)
adenosine 5-triphosphate disodium (ATP)alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
beet
branched-chain amino acids
calcium
caterpillar mushroom
cissus quadrangularis
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
fish protein
l-isoleucine
l-arginine
l-carnitine
l-citrulline
l-leucine
l-valine
maca
magnesium
ornithine alpha-ketoglutarate
phytocannabinoids
potassium
sardines
black ginger
tongkat ali
Urolithin A
vitamin D
whey protein
atractylodes
cistanche
electrolytes blend (proprietary)
camphor oil
chickpea protein
brown rice protein
AMP-activated protein kinase (AMPK)
Aralia
Arginine Alpha Ketoglutarate
Antler
Arginine Creatine
Alpha-ketoisocaproic acid
Algal protein
Alpha hydroxyisocaproic acid
Animal protein
Beef Protein
Beef
Beef liver
Bovine Protein
beta-lactoglobulin
Banyan
Ba Ji Tian
BCAA
Casein
Chinese Silkvine
Chinese Mountain Ant
Cyathula
Chuchuhuasi
Creatine
Chicken
Deer Velvet
Eurycomanone
Egg
Eurycoma Longifolia
Ecdysteroids
Ecdysterone
Egg protein
Fish
Guanidinoacetic acid
Ginsenosides
Isoleucine
Milk Protein
Quinoa Protein
salt
Other health conditions supported by Casein
Athletic and Exercise AidsBody Building
Calcium Deficiency
Muscle Tone (lack of)