Evidence supporting the use of: Casein
For the health condition: Muscle Tone (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Casein is a milk-derived protein commonly used in nutritional supplements, especially in sports and fitness contexts. Its primary claim to supporting or treating "muscle tone" is based on its slow digestion and absorption profile, which provides a sustained release of amino acids into the bloodstream. Multiple randomized controlled trials and meta-analyses have demonstrated that casein supplementation, particularly when consumed before sleep, enhances muscle protein synthesis and helps reduce muscle protein breakdown overnight (Res PT et al., 2013). This can be especially beneficial for individuals experiencing reduced muscle tone due to inactivity, aging (sarcopenia), or illness.
Casein’s efficacy is considered comparable to other complete proteins like whey, though its slower absorption makes it particularly suited for prolonged periods without dietary protein intake. Scientific evidence supports its effectiveness in increasing lean muscle mass and strength when combined with resistance training. However, it should be noted that “muscle tone” is not a clinical term and generally refers to the appearance or firmness of muscles, which is more directly influenced by muscle mass and physical activity than by any single dietary factor. Overall, casein is a scientifically validated ingredient for supporting muscle maintenance and growth, thereby indirectly supporting what is commonly referred to as "muscle tone."
Other ingredients used for Muscle Tone (lack of)
adenosine 5-triphosphate disodium (ATP)Algal protein
Alpha hydroxyisocaproic acid
alpha-ketoglutarate (AKG)
Alpha-ketoisocaproic acid
amino acids
AMP-activated protein kinase (AMPK)
animal protein
antler
Aralia
arginine alpha ketoglutarate
arginine creatine
ashwagandha
astaxanthin
atractylodes
ba ji tian
banyan
BCAA
beef
Beef liver
Beef Protein
beet
beta-lactoglobulin
black ginger
bovine protein
branched-chain amino acids
brown rice protein
calcium
camphor oil
casein
caterpillar mushroom
chickpea protein
Chinese mountain ant
Chinese silkvine
chuchuhuasi
Cissus quadrangularis
cistanche
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cordyceps
creatine
creatine monohydrate
Cyathula
deer velvet
ecdysteroids
ecdysterone
egg
Egg protein
electrolytes blend (proprietary)
Eurycoma Longifolia
eurycomanone
fish
fish protein
Ginsenosides
guanidinoacetic acid
HMB hydroxymethylbutyrate
hydroxymethylbutyrate
Isoleucine
L-arginine
l-carnitine
L-citrulline
l-isoleucine
L-leucine
L-valine
Legume protein
maca
magnesium
maral root
Marine protein
Methylxanthine
Milk Protein
Mineral blend
ornithine alpha-ketoglutarate
Phosphatidic Acid
Phosphocreatine
phytocannabinoids
Phytoecdysteroid
potassium
Premna
Quinoa Protein
Safed musli
salt
Shilajit
Sida cordifolia
Tongkat ali
Turkesterone
Urolithin A
Ursolic Acid
vitamin D
Whey protein
Withanolides
Xanthine
Xanthophyll
Other health conditions supported by casein
Athletic and Exercise AidsBody Building
Calcium Deficiency
Muscle Tone (lack of)
