Evidence supporting the use of: Citrulline aspartate
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrulline aspartate is primarily investigated for its effects on exercise performance, fatigue reduction, and ammonia clearance, rather than directly for treating low muscle tone (hypotonia). The scientific evidence supporting its use for improving or restoring muscle tone specifically is limited and indirect. Some studies have shown that citrulline aspartate supplementation can reduce sensations of fatigue and improve muscle endurance during exercise, possibly by enhancing ammonia clearance and stimulating the urea cycle, thus reducing metabolic stress on muscles. A few small clinical trials, mainly in athletes or individuals with fatigue, have reported improved physical performance and reduced muscle soreness. However, these effects pertain mostly to exercise-induced muscle fatigue, not the medical condition of hypotonia, which is usually neurological or genetic in origin. There are no robust clinical trials or guidelines supporting citrulline aspartate for the specific treatment of muscle tone abnormalities. Most evidence comes from studies on athletic performance or fatigue rather than muscle tone disorders. Thus, while there is some scientific rationale for its use in muscle performance, the evidence for its efficacy in treating lack of muscle tone is weak and indirect.

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