Creatine gluconate is a form of creatine, a compound that has been extensively studied for its effects on muscle strength, mass, and function. The majority of scientific evidence supporting the use of creatine for muscle tone (or muscle function and maintenance) comes from studies on creatine monohydrate, the most widely researched form. Creatine supplementation has been shown to increase phosphocreatine stores in muscle, enhance ATP regeneration during high-intensity exercise, and promote muscle protein synthesis. This leads to improved muscle strength, mass, and potentially better muscle tone, especially in people with muscle weakness or sarcopenia.

While creatine gluconate is less studied specifically than monohydrate, it is presumed to have similar effects since it serves as a creatine source. There is no significant evidence that gluconate offers advantages over other forms except for possibly improved solubility or taste. For individuals with muscle tone deficits due to inactivity, aging, or certain conditions, creatine supplementation (in general) is considered effective and is supported by clinical trials and meta-analyses. The evidence rating is not maximal (3/5) because direct studies on creatine gluconate are lacking, but the broader creatine literature is robust. Traditional use of creatine for muscle tone is minimal; its use is based on modern scientific research.