Evidence supporting the use of: Creatine glutamine
For the health condition: Muscle Tone (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Creatine and glutamine are both well-studied supplements in the context of muscle health, though their roles differ. Creatine is supported by robust scientific evidence for improving muscle strength, power, and mass, particularly in conjunction with resistance training. It acts by replenishing adenosine triphosphate (ATP) stores in muscle cells, which supports energy production during high-intensity, short-duration activities. Numerous randomized controlled trials and meta-analyses have shown that creatine supplementation increases muscle mass and enhances muscle function, making it a validated intervention for improving muscle tone, especially in populations with muscle weakness or sarcopenia.
Glutamine, on the other hand, is an amino acid involved in immune function and gut health. It is often marketed for muscle recovery, but scientific evidence supporting its effectiveness in directly increasing muscle tone or mass is limited compared to creatine. Some studies have investigated glutamine’s role in reducing muscle soreness or aiding recovery, but results are inconsistent.
Combining creatine and glutamine is sometimes promoted for overall muscle support. However, the evidence base for improved muscle tone primarily applies to creatine. In summary, creatine (not glutamine) is scientifically validated for supporting muscle tone, with a strong evidence base (rated 4/5), while glutamine’s role is much less clear.
More about Creatine glutamine
More about Muscle Tone (lack of)
Other ingredients used for Muscle Tone (lack of)
adenosine 5-triphosphate disodium (ATP)alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
beet
branched-chain amino acids
calcium
caterpillar mushroom
Cissus quadrangularis
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
fish protein
l-isoleucine
L-arginine
l-carnitine
L-citrulline
L-leucine
L-valine
maca
magnesium
ornithine alpha-ketoglutarate
phytocannabinoids
potassium
black ginger
Tongkat ali
Urolithin A
vitamin D
Whey protein
atractylodes
cistanche
electrolytes blend (proprietary)
camphor oil
chickpea protein
brown rice protein
AMP-activated protein kinase (AMPK)
Aralia
arginine alpha ketoglutarate
antler
arginine creatine
Alpha-ketoisocaproic acid
Algal protein
Alpha hydroxyisocaproic acid
animal protein
Beef Protein
beef
Beef liver
bovine protein
beta-lactoglobulin
banyan
ba ji tian
BCAA
casein
Chinese silkvine
Chinese mountain ant
Cyathula
chuchuhuasi
creatine
deer velvet
eurycomanone
egg
Eurycoma Longifolia
ecdysteroids
ecdysterone
Egg protein
fish
guanidinoacetic acid
Ginsenosides
hydroxymethylbutyrate
HMB hydroxymethylbutyrate
Isoleucine
Legume protein
Mineral blend
maral root
Marine protein
Milk Protein
Methylxanthine
Phosphocreatine
Premna
Phytoecdysteroid
Phosphatidic Acid
Quinoa Protein
Safed musli
salt
Sida cordifolia
Shilajit
Turkesterone
Ursolic Acid
Withanolides
Xanthine
Xanthophyll
Other health conditions supported by Creatine glutamine
Athletic and Exercise AidsFatigue
Muscle Tone (lack of)
Muscular Dystrophy
Wasting