Evidence supporting the use of: Creatine leucine
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creatine and leucine are both well-studied compounds in the context of muscle physiology, although they are traditionally supplemented separately rather than as a combined ingredient. Creatine is one of the most researched ergogenic aids and has been consistently shown in scientific studies to increase muscle mass, improve muscle strength, and enhance muscle function, particularly in populations with muscle weakness or wasting (e.g., elderly, patients with neuromuscular diseases). Creatine supplementation increases phosphocreatine stores in muscles, improving energy availability for muscle contractions and facilitating muscle protein synthesis.

Leucine is an essential branched-chain amino acid (BCAA) that plays a key role in stimulating muscle protein synthesis via activation of the mTOR pathway. It is often singled out as the most potent BCAA for initiating muscle growth and repair. Clinical studies have shown that leucine supplementation can help prevent muscle loss and promote muscle protein synthesis, particularly in older adults or those experiencing muscle wasting.

There is strong scientific validation for the use of both creatine and leucine (individually) to support and improve muscle tone, especially in cases of sarcopenia, rehabilitation, or muscle atrophy. Their combined use is logical, though most studies have examined them separately. The overall evidence supporting creatine and leucine for muscle tone is robust, justifying a high evidence rating.

More about Creatine leucine
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Other health conditions supported by Creatine leucine

Athletic and Exercise Aids
Energy (lack of)
Muscle Tone (lack of)
Wasting

Products containing Creatine leucine

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