Evidence supporting the use of: Creatine Pyruvate
For the health condition: Muscle Tone (lack of)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Creatine Pyruvate is a compound combining creatine and pyruvic acid, used as a dietary supplement. Scientific interest in creatine pyruvate for muscle function is based on the established role of creatine in supporting muscle energy metabolism and the potential benefits of pyruvate for aerobic endurance. However, direct evidence for creatine pyruvate specifically improving "muscle tone" (which often refers to the baseline level of muscle contraction or firmness) is limited.
Most of the available research focuses on creatine supplementation in general, which is well-documented to enhance muscle strength, power, and mass, especially in the context of resistance training or muscle weakness. Studies such as Jäger et al. (2008) have shown that creatine pyruvate supplementation can improve exercise performance and increase muscle creatine content, but these effects are more related to muscle performance and endurance rather than direct improvements in resting muscle tone or treatment of hypotonia (lack of muscle tone).
There is a lack of robust clinical trials specifically investigating creatine pyruvate for treating or supporting conditions characterized by lack of muscle tone, such as neuromuscular diseases. The evidence base is therefore rated low (2/5), with most support extrapolated from broader creatine research and a few small studies on the combined supplement. Further research is needed to establish its efficacy for this specific indication.
More about Creatine Pyruvate
More about Muscle Tone (lack of)
Other ingredients used for Muscle Tone (lack of)
adenosine 5-triphosphate disodium (ATP)alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
beet
branched-chain amino acids
calcium
caterpillar mushroom
cissus quadrangularis
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
fish protein
l-isoleucine
l-arginine
l-carnitine
l-citrulline
l-leucine
l-valine
maca
magnesium
ornithine alpha-ketoglutarate
phytocannabinoids
potassium
sardines
black ginger
tongkat ali
Urolithin A
vitamin D
whey protein
atractylodes
cistanche
electrolytes blend (proprietary)
camphor oil
chickpea protein
brown rice protein
AMP-activated protein kinase (AMPK)
Aralia
Arginine Alpha Ketoglutarate
Antler
Arginine Creatine
Alpha-ketoisocaproic acid
Algal protein
Alpha hydroxyisocaproic acid
Animal protein
Beef Protein
Beef
Beef liver
Bovine Protein
beta-lactoglobulin
Banyan
Ba Ji Tian
BCAA
Casein
Chinese Silkvine
Chinese Mountain Ant
Cyathula
Chuchuhuasi
Creatine
Chicken
Deer Velvet
Egg
Ecdysteroids
Ecdysterone
Egg protein
Isoleucine
Milk Protein
Quinoa Protein
salt
Other health conditions supported by Creatine Pyruvate
Athletic and Exercise AidsEnergy (lack of)
Fatigue
Muscle Tone (lack of)
Wasting