Evidence supporting the use of: Ecdysteroids
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ecdysteroids are a class of steroid hormones found primarily in insects and some plants (notably spinach and quinoa). In recent years, certain ecdysteroids, especially 20-hydroxyecdysone (20E), have gained attention for their potential anabolic effects in mammals, including humans. Several preclinical studies (in rodents) have shown that ecdysteroids can increase muscle mass and improve muscle protein synthesis, often without the typical androgenic side effects associated with anabolic steroids. For instance, a 2015 study published in “Archives of Toxicology” demonstrated that 20E increased grip strength and muscle fiber size in rats.

However, human data are limited and not robust. Small-scale studies and some athletic supplement literature suggest possible improvements in muscle performance and body composition, but these are typically underpowered, short-term, and sometimes lack rigorous controls. There is no strong clinical evidence to support the use of ecdysteroids specifically for treating conditions characterized by lack of muscle tone (such as hypotonia). The interest in ecdysteroids for muscle support is based more on promising preclinical data and anecdotal use rather than established clinical trials. Therefore, while the use of ecdysteroids to support muscle tone has some scientific plausibility, the evidence is currently weak and insufficient to recommend it as a treatment for lack of muscle tone in medical practice.

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