Evidence supporting the use of: Eurycomanone
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eurycomanone is a key bioactive compound found in Eurycoma longifolia (Tongkat Ali), a plant traditionally used in Southeast Asian medicine. Recent scientific research has explored its potential effects on muscle function, particularly in relation to muscle strength and tone. Several animal and limited human studies suggest that Eurycomanone may support muscle health by promoting testosterone production, enhancing protein synthesis, and reducing muscle fatigue. For example, some clinical trials have shown modest improvements in muscle strength and lean body mass in men taking standardized Tongkat Ali extracts, which contain Eurycomanone as a primary component. The proposed mechanism involves increased free testosterone and reduced cortisol, contributing to a more anabolic (muscle-building) environment. However, direct evidence specifically linking Eurycomanone supplementation to significant improvement in muscle tone (especially in pathological conditions characterized by muscle hypotonia) is relatively sparse. Most available studies are small, short-term, or use whole plant extracts rather than isolated Eurycomanone. Thus, while there is emerging scientific interest and some supportive evidence, it remains preliminary and further research is needed to fully validate Eurycomanone’s efficacy for improving muscle tone in clinical settings.

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