Evidence supporting the use of: Human growth hormone
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Human growth hormone (HGH) is scientifically validated for use in certain conditions characterized by poor muscle tone, primarily when the underlying cause is growth hormone deficiency. In children and adults with confirmed deficiency, HGH replacement therapy has been shown to improve muscle mass, strength, and physical function. Clinical trials and longitudinal studies have documented these effects, with improvements in lean body mass and reductions in fat mass. However, outside of this specific medical indication, the evidence for HGH improving muscle tone in healthy individuals or those with muscle weakness unrelated to HGH deficiency is weak or lacking.

HGH is not approved for general muscle enhancement due to risks such as edema, joint pain, insulin resistance, and potential for misuse. Its use should be limited to patients with diagnosed deficiencies or specific clinical syndromes (like muscle wasting in HIV/AIDS, where some evidence exists for benefit). For the general population or for age-related muscle loss (sarcopenia), systematic reviews and controlled trials have not shown consistent, significant improvements in muscle strength or function. Therefore, while there is scientific support for HGH in the context of deficiency-related muscle tone issues, its broader use for muscle tone is not substantiated by strong evidence.

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Products containing Human growth hormone

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