Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-arginine is an amino acid that plays a role in protein synthesis and serves as a precursor to nitric oxide, a molecule involved in vasodilation and blood flow. The scientific rationale for using L-arginine to support muscle tone or address lack of muscle tone (hypotonia) primarily rests on its involvement in muscle metabolism and blood supply. Some clinical studies have investigated L-arginine supplementation in the context of exercise performance and muscle growth, suggesting it may enhance blood flow to muscles and support recovery by increasing nitric oxide levels. However, the direct evidence for L-arginine improving muscle tone specifically in individuals with hypotonia or clinically significant muscle weakness is limited and inconclusive.

Most research focuses on its potential to enhance exercise-induced muscle gains or endurance rather than correcting underlying muscle tone deficits. A few small-scale studies suggest that L-arginine, when combined with resistance training, may result in modest improvements in muscle mass or strength, especially in older adults. Nevertheless, these effects are generally mild, and the studies often have methodological limitations such as small sample sizes and short durations. Overall, while there is a plausible biological mechanism and some early-stage clinical data, robust evidence directly supporting the use of L-arginine for treating or significantly improving lack of muscle tone is lacking. Therefore, the evidence rating for this use is low.

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