Evidence supporting the use of: Ligustilide
For the health condition: Muscle Tone (lack of)
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Ligustilide is a major bioactive component of Angelica sinensis (“Dong Quai”), a traditional Chinese medicinal herb. Historically, Angelica sinensis and its constituents have been used in traditional Chinese medicine (TCM) to address conditions such as menstrual irregularities, pain, and conditions described as “blood deficiency,” which sometimes included symptoms of muscle weakness or poor muscle tone. Traditional literature and TCM formulations occasionally attribute a tonifying effect to Angelica sinensis, suggesting it may help strengthen or invigorate the body, but these claims are not specific or well-defined in terms of modern muscle physiology.
There is little direct scientific evidence supporting the use of ligustilide specifically for improving muscle tone or treating muscle weakness. Some preclinical studies suggest that ligustilide has anti-inflammatory and neuroprotective properties, and may help with muscle pain in animal models, but there is a lack of robust clinical trials or mechanistic studies directly linking ligustilide with improved muscle tone in humans. The traditional use is therefore not strongly supported by modern scientific evidence, and its historical application to “muscle tone” is inferred rather than explicit.
In summary, the use of ligustilide to support or treat lack of muscle tone is rooted in traditional herbal practice, with very limited direct evidence from modern scientific research.
Other ingredients used for Muscle Tone (lack of)
adenosine 5-triphosphate disodium (ATP)alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
beet
branched-chain amino acids
calcium
caterpillar mushroom
cissus quadrangularis
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
fish protein
l-isoleucine
l-arginine
l-carnitine
l-citrulline
l-leucine
l-valine
maca
magnesium
ornithine alpha-ketoglutarate
phytocannabinoids
potassium
sardines
black ginger
tongkat ali
Urolithin A
vitamin D
whey protein
atractylodes
cistanche
electrolytes blend (proprietary)
camphor oil
chickpea protein
brown rice protein
AMP-activated protein kinase (AMPK)
Aralia
Arginine Alpha Ketoglutarate
Antler
Arginine Creatine
Alpha-ketoisocaproic acid
Algal protein
Alpha hydroxyisocaproic acid
Animal protein
Beef Protein
Beef
Beef liver
Bovine Protein
beta-lactoglobulin
Banyan
Ba Ji Tian
BCAA
Casein
Chinese Silkvine
Chinese Mountain Ant
Cyathula
Chuchuhuasi
Creatine
Chicken
Deer Velvet
Egg
Ecdysteroids
Ecdysterone
Egg protein
Isoleucine
Milk Protein
Quinoa Protein
salt
Other health conditions supported by Ligustilide
Abdominal PainAlzheimer's Disease
Anxiety
Arthritis
Asthma
Backache
Bronchitis
Cardiovascular Disease
Chills
Circulation (poor)
Circulation (to the brain)
Colds (general)
Constipation (adults)
Constipation (children)
Cough (general)
Depression
Diarrhea
Digestion (poor)
Dizziness
Edema
Fatigue
Fibrosis
Gastritis
Heart (weakness)
Hypertension
Inflammation
Liver Detoxification
Migraine
Muscle Tone (lack of)
Neuralgia and Neuritis