Evidence supporting the use of: Ornithine ketoglutarate
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ornithine ketoglutarate (OKG) is occasionally used as a nutritional supplement in clinical settings to support muscle mass and function, particularly in patients who are elderly, critically ill, or have muscle wasting conditions. OKG is a salt formed from ornithine and alpha-ketoglutarate, both of which are involved in amino acid metabolism and the urea cycle. The rationale for its use is that OKG may promote protein synthesis, reduce muscle protein breakdown, and serve as a precursor for anabolic amino acids such as glutamine and arginine.

Some clinical studies, mostly small-scale and often focused on hospitalized or catabolic patients (e.g., those with trauma, burns, or chronic illnesses), have reported that OKG supplementation can help preserve muscle mass, improve nitrogen balance, and potentially enhance recovery. There is also limited evidence suggesting OKG may have beneficial effects on muscle strength or tone, especially in the context of muscle wasting rather than primary neuromuscular disorders. However, large, well-designed randomized controlled trials are lacking, and the evidence base is not robust enough to recommend OKG for general use in improving muscle tone in healthy individuals. Most guidelines do not include OKG for this indication outside of specific clinical contexts.

In summary, although there is some scientific evidence supporting the use of ornithine ketoglutarate for muscle wasting and related loss of muscle tone in clinical populations, the evidence is limited and not conclusive. Its use is not typically based on tradition or historical practices, but rather on preliminary scientific findings.

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Products containing Ornithine ketoglutarate

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