Evidence supporting the use of: Premna
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Premna is primarily used in traditional medicine systems, particularly in Ayurveda and other Southeast Asian herbal practices, for supporting musculoskeletal health, including conditions like lack of muscle tone (muscle weakness). In Ayurveda, Premna species—most notably Premna serratifolia (known as "Agnimantha")—are recognized as important ingredients in classical formulations such as Dashamoola, which is used to address "Vata" disorders affecting the nerves and muscles. Traditional texts describe its use for relieving muscular pain, weakness, and for promoting the overall strength and tone of the musculoskeletal system. However, the evidence for its efficacy in treating or supporting muscle tone is based on long-standing usage rather than systematically validated scientific studies. Contemporary pharmacological research on Premna species has focused largely on their anti-inflammatory, analgesic, and antioxidant properties, but direct clinical studies evaluating its impact on muscle tone or sarcopenia are lacking. Therefore, while there is a strong tradition of Premna being used for musculoskeletal complaints, including low muscle tone, robust scientific validation for this specific indication is still absent. Practitioners continue to rely on historical precedent and empirical use rather than clinical trial data for recommending Premna in this context.

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