Evidence supporting the use of: Testosterone precursor (unspecified)
For the health condition: Muscle Tone (lack of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Testosterone precursors (such as DHEA or androstenedione) are sometimes used to address muscle tone or muscle mass issues, particularly in cases of hypogonadism or age-related declines in endogenous testosterone. The scientific rationale is that these precursors can be converted in the body to testosterone, which has well-documented anabolic effects on skeletal muscle, contributing to increased muscle mass and potentially improved muscle tone. Clinical studies have shown that testosterone replacement therapy in individuals with clinically low testosterone levels can improve muscle strength and lean body mass. However, evidence supporting the use of over-the-counter testosterone precursors (especially in people with normal testosterone levels) is limited and inconsistent. Some studies have found minor increases in testosterone levels and lean mass with DHEA or androstenedione supplementation, but these effects are generally small and often not statistically significant. Furthermore, the use of such supplements is not universally recommended due to variability in conversion rates, potential side effects, and regulatory concerns. For individuals with clinically diagnosed testosterone deficiency, medical testosterone therapy—not precursors—is the standard of care. In summary, while there is a scientific basis for the potential of testosterone precursors to affect muscle tone via anabolic pathways, the direct evidence for their efficacy in treating lack of muscle tone (especially in otherwise healthy individuals) is weak to moderate at best.

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