Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine Alpha Ketoglutarate (AAKG) is widely marketed as a sports supplement, especially for supporting muscle growth, performance, and recovery. The theoretical basis for using AAKG in the muscular system rests on L-arginine’s role as a precursor to nitric oxide (NO), a molecule that can help dilate blood vessels and potentially increase blood flow to muscles during exercise. Alpha ketoglutarate, meanwhile, is involved in the Krebs cycle and may support energy production.

However, the scientific evidence supporting AAKG for muscle performance and growth is limited and mixed. Some small studies have shown modest improvements in measures like bench press repetitions or perceived muscle pump, but these findings are inconsistent and often involve small sample sizes or short durations. A review in the Journal of the International Society of Sports Nutrition (2012) concluded that arginine supplementation does not reliably increase nitric oxide production or improve strength and muscle mass in healthy, resistance-trained adults. Similarly, a 2017 review found no significant benefits of arginine-based supplements for muscle performance.

Despite its popularity and plausible mechanisms, AAKG’s efficacy for muscle support is not strongly validated by rigorous clinical evidence. Thus, its use is best described as supported by limited scientific rationale, with an evidence rating of 2 out of 5.

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Other body systems supported by arginine alpha ketoglutarate

Arteries
Blood
Circulatory System
Muscles

Products containing arginine alpha ketoglutarate

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