Ginsenosides, the primary active components of Panax ginseng, have garnered scientific interest for their potential effects on the muscular system. Several preclinical and clinical studies suggest that ginsenosides may contribute to muscle health through a variety of mechanisms. In animal models, ginsenosides have been shown to enhance muscle strength, reduce exercise-induced fatigue, and promote muscle protein synthesis. These effects are believed to be mediated by the modulation of oxidative stress, anti-inflammatory actions, and improvements in mitochondrial function within muscle cells.

Human studies, though limited, have reported that supplementation with ginseng extracts can improve exercise performance, reduce subjective fatigue, and potentially aid in recovery following intense physical activity. For example, some clinical trials have found improvements in endurance and reduced markers of muscle damage after ginseng supplementation. However, these studies often use whole ginseng extract rather than isolated ginsenosides, and results are somewhat variable depending on dosage, duration, and population studied.

While the traditional use of ginseng for vitality and stamina is well established, the direct scientific evidence linking purified ginsenosides to muscle support in humans remains moderate. More large-scale, controlled human trials are needed to clearly define the efficacy and optimal usage of ginsenosides for this purpose.