Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-Isoleucine is one of the three branched-chain amino acids (BCAAs), along with leucine and valine. These amino acids are considered essential, meaning they must be obtained from the diet, as the human body cannot synthesize them. L-Isoleucine plays a key role in muscle metabolism, immune function, hemoglobin production, and energy regulation.

Scientific studies have shown that BCAAs, including isoleucine, are important in supporting muscle protein synthesis and recovery, particularly in athletes and physically active individuals. Supplementation with BCAAs has been found to reduce markers of muscle damage and soreness after exercise, although the effects are often modest and sometimes attributed more to leucine than isoleucine specifically. Isoleucine, however, is thought to be particularly important for increasing glucose uptake into muscle cells and promoting energy production during exercise, which can help support muscle endurance and recovery.

Overall, the use of L-isoleucine to support the muscles body system is backed by scientific evidence, but most benefits are attributed to BCAA mixtures rather than isoleucine alone. The strength of evidence specifically for L-isoleucine is moderate (3/5), as much of the research does not isolate its effects from those of the other BCAAs. Still, its role in muscle metabolism and energy regulation justifies its inclusion in supplements aimed at supporting muscle health.

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