Evidence supporting the use of: L-isoleucine
For the body system: Muscles
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
L-Isoleucine is one of the three branched-chain amino acids (BCAAs), along with leucine and valine. These amino acids are considered essential, meaning they must be obtained from the diet, as the human body cannot synthesize them. L-Isoleucine plays a key role in muscle metabolism, immune function, hemoglobin production, and energy regulation.
Scientific studies have shown that BCAAs, including isoleucine, are important in supporting muscle protein synthesis and recovery, particularly in athletes and physically active individuals. Supplementation with BCAAs has been found to reduce markers of muscle damage and soreness after exercise, although the effects are often modest and sometimes attributed more to leucine than isoleucine specifically. Isoleucine, however, is thought to be particularly important for increasing glucose uptake into muscle cells and promoting energy production during exercise, which can help support muscle endurance and recovery.
Overall, the use of L-isoleucine to support the muscles body system is backed by scientific evidence, but most benefits are attributed to BCAA mixtures rather than isoleucine alone. The strength of evidence specifically for L-isoleucine is moderate (3/5), as much of the research does not isolate its effects from those of the other BCAAs. Still, its role in muscle metabolism and energy regulation justifies its inclusion in supplements aimed at supporting muscle health.
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adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Algae
Algal protein
Alpha hydroxyisocaproic acid
alpha-ketoglutarate (AKG)
Alpha-ketoisocaproic acid
amino acids
AMP-activated protein kinase (AMPK)
animal protein
animal Tissue
Anserina
antler
arachidonic acid
arginine alpha ketoglutarate
Arginine alpha-ketoisocaproate
Arginine aspartate
arginine creatine
Arginine malate
Arginine nitrate
Arginine silicate
arnica
ashwagandha
astaxanthin
avocado
ba ji tian
banana
BCAA
bee products
beef
Beef liver
Beef Protein
beet
beta-alanine
beta-hydroxybutyrate
bicarbonate
Biopeptide
black galingale
black ginger
black gram
Black willow
blue cohosh
bovine
bovine liver
bovine protein
branched-chain amino acids
bromelain
brown rice protein
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caffeine
calcium
camphor oil
cardarine
Carnosine
casein
Cetylated Fatty Acids
cherry
chia seed
chickpea protein
Chinese mountain ant
chloride
chuchuhuasi
citrate malate
coca
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coenzyme Q10 (CoQ10)
colostrum
conjugated linoleic acid (CLA)
cordyceps
cramp bark
creatine
creatine monohydrate
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d-alpha tocopherol
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date
deer velvet
devil's claw
dextrose
Dimethyl sulfoxide (DMSO)
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DL-Methionine
dong quai root
ecdysteroids
ecdysterone
egg
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electrolytes blend (proprietary)
elk antler
emu oil
epicatechin
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eucommia
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forskohlii root
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guanidinoacetic acid
guanidinopropionic acid (GPA )
guelder rose
Haematococcus pluvialis
hairy arnica
herbal blend (proprietary)
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icariin
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Isoleucine
isomaltulose
kale
ketosterones
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L-arginine
l-carnitine
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lactalbumin
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lipids
magnesium
malic acid
maral root
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Methylxanthine
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NADH
nicotinamide riboside
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Pea
Peppermint
Peptides
Phosphatidic Acid
Phosphocreatine
phosphorus
phytocannabinoids
Phytoecdysteroid
Plankton
polyphenols
potash
potassium
Propionyl-L-Carnitine
protein
proteolytic enzymes
Puerain
pyruvate
Qin Jiao
quinoa
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Rhaponticum
rhizome
ribose
rue
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salt
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siler root
solomon's seal
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soybean
specialized pro-resolving mediators (SPMs)
spinach
spirulina
squawvine
suma
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trace minerals
Tribulus Terrestris
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Turkesterone
turmeric
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ubiquinol
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Ursolic Acid
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vitamin D
vitamin D3
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