Evidence supporting the use of: Rue
For the body system: Muscles
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Rue (Ruta graveolens) has a long history of use in traditional herbal medicine, particularly within Mediterranean and European cultures. Historically, rue has been applied externally and taken internally for various ailments, including muscle pain, cramps, and rheumatism. Folk medicine texts from the Middle Ages and Renaissance often mention rue as a remedy for sore muscles, sprains, and to "strengthen the sinews." The plant contains several active compounds, such as rutin and various furanocoumarins, which have been studied for their anti-inflammatory and antispasmodic properties, though these studies are limited and mostly in vitro or in animal models.
Despite this traditional background, there is minimal scientific evidence supporting rue’s efficacy in supporting the muscular system. Modern clinical trials are lacking, and most recommendations for its use in muscle health are based on historical practice rather than validated research. Moreover, rue can be toxic in high doses or when used improperly, causing photodermatitis and other side effects. In summary, while rue’s use for muscle support is justified by tradition, there is little direct scientific validation for its efficacy or safety in this context.
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acetyl l-carnitineadenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
astaxanthin
beet
beta-alanine
bovine
bovine liver
branched-chain amino acids
bromelain
caffeine
calcium
cherry
chloride
coenzyme Q10 (CoQ10)
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
turmeric
d-alpha tocopherol
devil's claw
dong quai root
fish protein
forskohlii root
l-isoleucine
iron
kale
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-carnosine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-proline
l-taurine
l-threonine
l-valine
magnesium
malic acid
maltodextrin
maltose
methylsulfonylmethane (MSM)
milk
nicotinamide riboside
ornithine alpha-ketoglutarate
peppermint oil
phosphorus
phytocannabinoids
potassium
protein
quinoa
rhizome
sardines
black ginger
soybean
specialized pro-resolving mediators (SPMs)
spinach
spirulina
tongkat ali
ubiquinol
Urolithin A
vitamin B
vitamin C
vitamin D
vitamin D3
water
watermelon
whey protein
white willow
β-nicotinamide mononucleotide (NMN)
suma
squawvine
sodium salt
solomon's seal
siler root
eucommia
electrolytes blend (proprietary)
guelder rose
polyphenols
trace minerals
wintergreen
camphor oil
menthol oil
wheat germ
wood betony
herbal blend (proprietary)
algae
chickpea protein
brown rice protein
AMP-activated protein kinase (AMPK)
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17a-di methyl-bol
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2, 17a-dimethyl-17b-hydroxy-5a-androstan-1-ene-3-one
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Animal Tissue
Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
Avocado
Anserina
Alpha-ketoisocaproic acid
Acetylcholine
adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine alpha-ketoisocaproate
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Animal protein
Blue Cohosh
Biopeptide
Beta-hydroxybutyrate
Bicarbonate
Beef Protein
Black galingale
Beef
Beef liver
Bovine Protein
Black Gram
Black willow
Ba Ji Tian
Bee products
banana
BCAA
Chia seed
Casein
Cardarine
Chinese Mountain Ant
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Citrate malate
Cyathula
Curcuminoid
Cramp Bark
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Coconut Water
Cetylated Fatty Acids
Creatine
Chicken
Curcuma
C-Phycocyanin
Cyanotis arachnoides
DL-Methionine
Deer Velvet
Date
D-Ribose
Dextrose
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Dipsacus
Dipeptide
epicatechin
Epistane
Egg
Erythrina
Elk antler
Emu Oil
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Essential Oil Blend
Egg protein
fibroblast growth factor
glucose
Glycine
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Milk Protein
Phosphate Salt
Potash
Quinoa Protein
salt
Soy Protein