Evidence supporting the use of: SOD (Superoxide Dismutase, antioxidant activity)
For the body system: Muscles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Superoxide Dismutase (SOD) is an important antioxidant enzyme that catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide, thereby reducing oxidative stress in cells. There is some scientific evidence suggesting that SOD may play a role in supporting muscle health, particularly in the context of exercise-induced oxidative stress. Intense physical activity increases the production of reactive oxygen species (ROS), which can damage muscle tissue and impair recovery. Several animal studies and limited human trials have shown that increasing SOD activity (either via supplementation or dietary sources) can reduce markers of oxidative stress and muscle damage following strenuous exercise. For example, studies have shown that SOD-rich melon extract supplementation reduced muscle fatigue and oxidative damage in athletes. However, the bioavailability of orally administered SOD is debated, as the enzyme can be degraded in the digestive tract, although some formulations claim improved stability and absorption. While SOD's role as an endogenous cellular defense is well-established, evidence supporting the efficacy of oral SOD supplementation specifically for muscle health in humans remains limited and mixed. Therefore, while there is a scientific rationale and some preliminary data, the overall quality and quantity of evidence supporting SOD as a muscle health supplement is modest, warranting a rating of 2 out of 5.

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Products containing SOD (Superoxide Dismutase, antioxidant activity)

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