Evidence supporting the use of: Transforming growth factor
For the body system: Muscles

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Transforming Growth Factor (TGF), particularly TGF-beta, is a cytokine involved in the regulation of cellular growth, differentiation, and repair. In the context of the muscle body system, scientific evidence supports TGF-beta's role in muscle regeneration and repair, primarily through its effects on muscle satellite cells and extracellular matrix remodeling. However, its role is complex: while TGF-beta is crucial for proper tissue repair after muscle injury, excessive or prolonged TGF-beta signaling can lead to fibrosis and impaired muscle function. Animal studies have shown that TGF-beta is upregulated following muscle injury, and modulating its activity can influence muscle healing outcomes. Some experimental therapies aim to inhibit TGF-beta signaling to prevent fibrotic scar formation in muscular dystrophies and other chronic muscle diseases. There is no substantial evidence that direct supplementation or administration of TGF is used in clinical practice to support healthy muscle growth or function. The evidence for TGF's beneficial role in muscle repair is largely preclinical and mechanistic, rather than based on human clinical trials demonstrating improvements in muscle health through TGF administration. Therefore, while TGF plays a scientifically documented role in muscle physiology, its therapeutic use to support the muscle system remains under investigation and is not established in routine practice.

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