Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ubiquinol, the reduced and active form of coenzyme Q10 (CoQ10), is scientifically recognized for its role in cellular energy production and antioxidant defense, particularly in tissues with high-energy demands such as skeletal and cardiac muscle. CoQ10 is a key component of the mitochondrial electron transport chain, facilitating ATP generation necessary for muscle contraction and endurance. Several clinical studies have explored its benefits for muscle function, especially in populations with CoQ10 deficiency, statin-induced myopathy, or age-related decline in mitochondrial function. Evidence suggests that supplementation with ubiquinol may improve exercise performance, reduce fatigue, and alleviate mild muscle discomfort in specific groups, such as older adults or those on statin medications. However, results in healthy, athletic populations are mixed, with some trials reporting modest improvements in exercise capacity and others showing minimal effect. Meta-analyses generally confirm the safety of ubiquinol supplementation and indicate potential benefits for individuals with documented deficiencies or mitochondrial dysfunction. Overall, the evidence is moderate, and ubiquinol is supported by mechanistic rationale and clinical trials for muscle support, primarily in targeted groups rather than the general healthy population.

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Other body systems supported by ubiquinol

Products containing ubiquinol

Designs For Health COQ200 200mg
Designs For Health CoQnol™ 100mg
Douglas Laboratories Ubiquinol-QH
Douglas Laboratories Ubiquinol-QH