Evidence supporting the use of: Vitamin B1 (thiamine diphosphate)
For the body system: Muscles
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B1, also known as thiamine, is an essential nutrient that plays a critical role in carbohydrate metabolism and energy production. Its active form, thiamine diphosphate (also called thiamine pyrophosphate), functions as a coenzyme in several biochemical pathways, most notably the decarboxylation of pyruvate to acetyl-CoA in the Krebs cycle, which is fundamental for ATP (energy) production in all cells, including muscle cells. Adequate ATP production is essential for muscle contraction, repair, and overall function.
Thiamine deficiency is well known to cause muscle weakness and fatigue, as seen in conditions such as beriberi. In such deficiency states, supplementation leads to a clear and rapid improvement in muscle strength. However, for individuals without a deficiency, evidence supporting thiamine supplementation for enhanced muscle function or growth is limited. Most scientific studies focus on populations with clinical thiamine deficiency or on diseases that impair thiamine status, rather than on healthy individuals or athletes.
In summary, thiamine is scientifically validated as essential for normal muscle function due to its role in energy metabolism. Supplementation is clearly beneficial in deficiency states, but there is only modest evidence to support its use for enhancing muscle performance or health in individuals with adequate thiamine status. Thus, the overall evidence rating is moderate.
More about Vitamin B1 (thiamine diphosphate)
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acetyl l-carnitineadenosine 5-triphosphate disodium (ATP)
alpha-ketoglutarate (AKG)
amino acids
amylopectin
ashwagandha
astaxanthin
beet
beta-alanine
bovine
bovine liver
branched-chain amino acids
bromelain
caffeine
calcium
cherry
chloride
coenzyme Q10 (CoQ10)
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
turmeric
d-alpha tocopherol
devil's claw
dong quai root
fish protein
forskohlii root
l-isoleucine
iron
kale
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-carnosine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-proline
l-taurine
l-threonine
l-valine
magnesium
malic acid
maltodextrin
maltose
methylsulfonylmethane (MSM)
milk
nicotinamide riboside
ornithine alpha-ketoglutarate
peppermint oil
phosphorus
phytocannabinoids
potassium
protein
quinoa
rhizome
sardines
black ginger
soybean
specialized pro-resolving mediators (SPMs)
spinach
spirulina
tongkat ali
ubiquinol
Urolithin A
vitamin B
vitamin C
vitamin D
vitamin D3
water
watermelon
whey protein
white willow
β-nicotinamide mononucleotide (NMN)
suma
squawvine
sodium salt
solomon's seal
siler root
eucommia
electrolytes blend (proprietary)
guelder rose
polyphenols
trace minerals
wintergreen
camphor oil
menthol oil
wheat germ
wood betony
herbal blend (proprietary)
algae
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2, 17a-dimethyl-17b-hydroxy-5a-androstan-1-ene-3-one
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Animal Tissue
Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
Avocado
Anserina
Alpha-ketoisocaproic acid
Acetylcholine
adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine alpha-ketoisocaproate
Arginine silicate
Animal protein
Blue Cohosh
Biopeptide
Beta-hydroxybutyrate
Bicarbonate
Beef Protein
Black galingale
Beef
Beef liver
Bovine Protein
Black Gram
Black willow
Ba Ji Tian
Bee products
banana
BCAA
Chia seed
Casein
Cardarine
Chinese Mountain Ant
Carnosine
Citrate malate
Cyathula
Curcuminoid
Cramp Bark
Chuchuhuasi
Cyanotis Vaga
Coca
Coconut Water
Cetylated Fatty Acids
Creatine
Chicken
Curcuma
C-Phycocyanin
Cyanotis arachnoides
DL-Methionine
Deer Velvet
Date
D-Ribose
Dextrose
Dimethyl sulfoxide (DMSO)
Dipsacus
Dipeptide
epicatechin
Epistane
Egg
Erythrina
Elk antler
Eurycoma Longifolia
Emu Oil
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Essential Oil Blend
Egg protein
Fish
Fatty acids
fibroblast growth factor
glucose
Glycine
Isoleucine
Milk Protein
Phosphate Salt
Potash
Quinoa Protein
salt
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Other body systems supported by Vitamin B1 (thiamine diphosphate)
BrainCirculatory System
Digestive System
Gastrointestinal Tract
Heart
Immune System
Liver
Mitochondria
Muscles
Nerves