Evidence supporting the use of: Cysteine compounds (unspecified)
For the body system: Nails

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cysteine is a sulfur-containing amino acid that plays a crucial role in the synthesis of keratin, the primary structural protein in nails, skin, and hair. Scientific evidence supports that cysteine is an important building block for keratin, contributing to the strength and resilience of nails. Some studies have shown that supplementation with cysteine (often in the form of N-acetylcysteine or L-cysteine) may improve nail quality in individuals with deficiencies or specific nail disorders. However, robust clinical trials in healthy populations are limited, and most available evidence comes from biochemical studies, small-scale trials, or research on related compounds such as biotin and methionine, which also influence keratin production.

While cysteine is an essential component in the structure of nails, direct evidence for supplementation improving nail health in the general population is moderate. It is included in some dietary supplements marketed for nail health, often alongside other nutrients. Overall, the role of cysteine in supporting the nails is scientifically plausible and partially supported by evidence, but more large-scale, controlled studies are necessary to rate the evidence higher than 3 out of 5.

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