Evidence supporting the use of: Asarum sieboldii
For the health condition: Nausea and Vomiting

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Asarum sieboldii, also known as saishin or Japanese wild ginger, has a long history of use in traditional East Asian medicine, particularly in Chinese and Japanese Kampo medicine. It is commonly included in classic herbal formulas (such as Maoto and Shoseiryuto) that are used to address symptoms like cough, headache, and sometimes digestive complaints including nausea and vomiting. The rationale for its use is largely based on traditional theories, such as its supposed ability to "dispel cold" and "regulate qi." Historical texts describe its application for conditions involving gastrointestinal upset, including nausea and vomiting, especially when related to cold or dampness. However, modern scientific evidence supporting these uses is limited. While there are some animal studies and a few in vitro reports suggesting possible antiemetic and anti-inflammatory effects of certain compounds found in Asarum species, robust clinical trials in humans are lacking. Additionally, concerns exist about the safety of Asarum sieboldii due to the presence of aristolochic acids, which are nephrotoxic and potentially carcinogenic. Regulatory agencies in several countries have issued warnings or restrictions regarding its use. In summary, Asarum sieboldii's use for nausea and vomiting is primarily justified by traditional practice, with only modest preclinical evidence and insufficient clinical validation to support its efficacy or safety for this indication.

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