Citrus nobilis, commonly known as mandarin orange, has a long history of use in traditional medicine systems, particularly in East Asian practices such as Traditional Chinese Medicine (TCM). In these traditions, dried peel of Citrus nobilis (often referred to as "Chen Pi") is used to address digestive complaints, including nausea and vomiting. The rationale in TCM is based on the belief that Chen Pi helps regulate "Qi" in the digestive system, alleviating stagnation and promoting harmonious digestion.

While there is some preclinical research indicating that extracts from citrus peel may have bioactive compounds with antiemetic (anti-nausea) or prokinetic effects, robust clinical evidence specific to Citrus nobilis for the treatment of nausea and vomiting remains limited. Most available studies are either animal-based or in vitro, and often focus on related Citrus species. Therefore, the use of Citrus nobilis for nausea and vomiting is primarily justified by traditional use rather than modern scientific validation.

In conclusion, the evidence supporting Citrus nobilis for this indication is rooted in tradition, with only modest support from early-stage scientific studies, and a lack of well-designed human clinical trials to establish efficacy.