Evidence supporting the use of: Large-leaf Gentian
For the health condition: Nausea and Vomiting

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Large-leaf Gentian (Gentiana macrophylla) has a long history of traditional use in Chinese and other East Asian herbal medicine systems. It is commonly employed as a bitter tonic, with the root being the principal part used. In traditional Chinese medicine (TCM), the root is included in formulas intended to "clear heat" and "drain dampness," and is sometimes used to address digestive complaints, including nausea and vomiting, particularly when these symptoms are believed to be associated with liver or gallbladder imbalance. The rationale behind its use is rooted in the bitter principles (such as gentiopicroside and other iridoids) that are thought to stimulate digestive secretions and improve gastrointestinal function. However, while the traditional use is well documented, there is little in the way of modern scientific studies specifically examining the efficacy of Large-leaf Gentian for the treatment of nausea and vomiting. Most available pharmacological research focuses on its anti-inflammatory and hepatoprotective effects rather than direct antiemetic actions. Thus, the evidence supporting its use for nausea and vomiting is traditional in nature and can be considered modest, warranting further clinical investigation to substantiate these claims.

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