Evidence supporting the use of: Phthalides
For the health condition: Nausea and Vomiting

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Phthalides are a group of naturally occurring compounds most notably found in plants such as celery (Apium graveolens) and Ligusticum species (e.g., Ligusticum chuanxiong, a traditional Chinese medicinal herb). Their use for nausea and vomiting is primarily rooted in traditional medicine systems, particularly Traditional Chinese Medicine (TCM). In TCM, herbs containing phthalides, such as Chuanxiong, are often included in formulations to "regulate qi" and alleviate various symptoms, including digestive disturbances like nausea. However, the rationale is based on holistic and empirical approaches rather than on isolated pharmacological effects of phthalides themselves. Modern scientific validation specifically linking phthalides to antiemetic (anti-nausea and vomiting) effects remains limited. Most research on phthalides focuses on their vascular, neuroprotective, or anti-inflammatory properties. Few preclinical studies have explored their effects on gastrointestinal motility, but direct evidence for their use in treating nausea and vomiting in humans is lacking. As a result, the support for using phthalides for these symptoms is considered traditional, and the evidence level is low, reflecting the absence of robust clinical trials or mechanistic studies to confirm their efficacy.

More about Phthalides
More about Nausea and Vomiting

Products containing Phthalides

We currently have no products on Vitabase that contain this ingredient.