Plectranthus amboinicus (also known as Indian borage or Cuban oregano) has a long history of use in traditional medicine across several cultures, particularly in Asia, Africa, and the Caribbean. Traditional practitioners have employed the leaves of this plant to manage symptoms such as nausea, vomiting, indigestion, and other gastrointestinal complaints. The aromatic leaves are often used in teas, decoctions, or as a spice in food with the intent of soothing the stomach and reducing nausea. Ethnobotanical surveys have documented these uses in various regions, including India and the Caribbean.

However, direct scientific validation for the use of Plectranthus amboinicus specifically to treat or support nausea and vomiting is limited. While some in vitro and animal studies suggest the plant contains volatile oils and compounds (such as carvacrol and thymol) with antimicrobial, anti-inflammatory, and mild spasmolytic properties, clinical trials focused on antiemetic effects in humans are lacking. Therefore, while traditional use is well-established, the strength of scientific evidence remains weak, justifying a rating of 2 on the evidence scale.